Touchy thinking: interactivity improves planning

The effects of interactivity and ego depletion on planning were investigated using a sequential-task paradigm. Participants completed a 16-part trip-planning task in either a high-interactivity condition—where cards corresponding to events could be moved—or low-interactivity condition—during which moves were dictated to the experimenter and participants kept their hands down. Before that, half of the participants undertook an ego-depletion task. Planning performance was significantly better in the high than in the low-interactivity conditions; the main effect of ego depletion was never significant. These results suggest that interactivity augments working memory resources

Amplification of Primordial Magnetic Fields by Anisotropic Gravitational Collapse

If a magnetic field is frozen into a plasma that undergoes spherical compression then the magnetic field B varies with the plasma density \rho according to B \propto \rho^{2/3}. In the gravitational collapse of cosmological density perturbations, however, quasi-spherical evolution is very unlikely. In anisotropic collapses the magnetic field can be a much steeper function of gas density than in the isotropic case. We investigate the distribution of amplifications in realistic gravitational collapses from Gaussian initial fluctuations using the Zel'dovich approximation. Representing our results using a relation of the form B\propto \rho^{\alpha}, we show that the median value of \alpha can be much larger than the \alpha=2/3 resulting from spherical collapse, even if there is no initial correlation between magnetic field and principal collapse directions. These analytic arguments go some way towards understanding the results of numerical simulations.Comment: 9 pages, 4 figures. Submitted to MNRA

The effect of concrete wording on truth judgements : a preregistered replication and extension of Hansen & Wanke (2010)

When you lack the facts, how do you decide what is true and what is not? In the absence of knowledge, we sometimes rely on non-probative information. For example, participants judge concretely worded trivia items as more likely to be true than abstractly worded ones (the linguistic truth effect;Hansen & Wänke, 2010). If minor language differences affect truth judgements, ultimately they could influence more consequential political, legal, health, and interpersonal choices. This Registered Report includes two high-powered replication attempts of Experiment 1 from Hansen and Wänke (2010). Experiment 1a was a dual-site, in-person replication of the linguistic concreteness effect in the original paper-and-pencil format (n = 253, n = 246 in analyses). Experiment 1b replicated the study with an online sample (n = 237,n = 220 in analyses). In Experiment 1a, the effect of concreteness on judgements of truth (Cohen’sdz = 0.08; 95% CI: [–0.03, 0.18]) was smaller than that of the original study. Similarly, in Experiment 1b the effect (Cohen’s dz = 0.11; 95% CI [–0.01, 0.22]) was smaller than that of the original study. Collectively, the pattern of results is inconsistent with that of the original study

Downregulation of SREBP Inhibits Tumor Growth and Initiation by Altering Cellular Metabolism in Colon Cancer

Sterol regulatory element-binding proteins (SREBPs) belong to a family of transcription factors that regulate the expression of genes required for the synthesis of fatty acids and cholesterol. Three SREBP isoforms, SREBP1a, SREBP1c, and SREBP2, have been identified in mammalian cells. SREBP1a and SREBP1c are derived from a single gene through the use of alternative transcription start sites. Here we investigated the role of SREBP-mediated lipogenesis in regulating tumor growth and initiation in colon cancer. Knockdown of either SREBP1 or SREBP2 decreased levels of fatty acids as a result of decreased expression of SREBP target genes required for lipid biosynthesis in colon cancer cells. Bioenergetic analysis revealed that silencing SREBP1 or SREBP2 expression reduced the mitochondrial respiration, glycolysis, as well as fatty acid oxidation indicating an alteration in cellular metabolism. Consequently, the rate of cell proliferation and the ability of cancer cells to form tumor spheroids in suspension culture were significantly decreased. Similar results were obtained in colon cancer cells in which the proteolytic activation of SREBP was blocked. Importantly, knockdown of either SREBP1 or SREBP2 inhibited xenograft tumor growth in vivo and decreased the expression of genes associated with cancer stem cells. Taken together, our findings establish the molecular basis of SREBP-dependent metabolic regulation and provide a rationale for targeting lipid biosynthesis as a promising approach in colon cancer treatment

Open social science 101 : the case of registered reports

Have you ever tried to run a study building on published research and found that you could not replicate the main findings? In psychology, the so-called ‘replication crisis’ has led to a renewed methodological rigour, specifically around transparency in science. A practical outcome of this revolution is Registered Reports, a new submission format where authors submit their introduction, method, and analysis plan to a journal in a first stage. After reviews and potential revisions, if the Registered Report is accepted, the authors are guaranteed that their work will be published in the journal (stage 2 submission), independent of the findings. This format not only helps to improve study designs from the outset, leading to more reliable science, but also decreases publication bias, reducing the over-estimation of effects. Currently, 187 journals accept Registered Reports: the majority of these are in the psychology or biomedical fields, but there are now journals accepting this format in other social sciences (e.g., Psychology and Marketing, Journal of Development Economics, Journal of Experimental Political Science). In this talk, we intend to lay out the rationale for moving to open science, in psychology and beyond, highlighting the range of actions, from small steps to a larger overhaul of practices, that can be taken at researcher level. Two authors will also share their experience with Registered Reports, from their ECR and senior perspective

Prenatal glucocorticoid exposure in rats: programming effects on stress reactivity and cognition in adult offspring

Human epidemiological studies have provided compelling evidence that prenatal exposure to stress is associated with significantly increased risks of developing psychiatric disorders in adulthood. Exposure to excessive maternal glucocorticoids may underlie this fetal programming effect. In the current study, we assessed how prenatal dexamethasone administration during the last week of gestation affects stress reactivity and cognition in adult offspring. Stress reactivity was assessed by evaluating anxiety-like behavior on an elevated plus maze and in an open field. In addition, to characterize the long-term cognitive outcomes of prenatal exposure to glucocorticoids, animals were assessed on two cognitive tasks, a spatial reference memory task with reversal learning and a delayed matching to position (DMTP) task. Our results suggest that prenatal exposure to dexamethasone had no observable effect on anxiety-like behavior, but affected cognition in the adult offspring. Prenatally dexamethasone-exposed animals showed a transient deficit in the spatial reference memory task and a trend to faster acquisition during the reversal-learning phase. Furthermore, prenatally dexamethasone-treated animals also showed faster learning of new platform positions in the DMTP task. These results suggest that fetal overexposure to glucocorticoids programs a phenotype characterized by cognitive flexibility and adaptability to frequent changes in environmental circumstances. This can be viewed as an attempt to increase the fitness of survival in a potentially hazardous postnatal environment, as predicted by intrauterine adversity. Collectively, our data suggest that prenatal exposure to dexamethasone in rats could be used as an animal model for studying some cognitive components of related psychiatric disorders